Investigate Gut Microbiome, Diet, Parasites and Antibiotic Resistance Genes in Macaques

Macaques experience a range of habitats that have profound impacts on their social interactions, dispersal patterns, foraging behaviors, diet, and exposure to parasites, all of which can influence the diversity, community structure, and interactions among different groups of microbes living in the gut. Recent findings from our lab show that the macaque diet to be centrally important in determining gut microbial communities; however, exposure to parasites can supersede these diet effects and is strongly associated with a greater abundance of pathogenic bacteria. A student joining the research group would test the generalisability of earlier lab results of long-tailed macaques (from Bali, Indonesia and Singapore) by helping to characterise the microbial communities, diet, and parasites of a new group of macaques (toque macaques, Sri Lanka), and perhaps even explore the potential for antibiotic resistance gene transmission due to increased urbanization.
Name of research group, project, or lab
Hollocher Lab
Logistics Information:
Project categories
Biological Sciences
Student ranks applicable
First Year
Sophomore
Junior
Hours per week
1 credit / 3-6 hours
Compensation
Research for Credit
Number of openings
1
Techniques learned
- Training in molecular laboratory techniques- DNA extractions, PCR, gel electrophoresis
- Data Analysis, visualization and Interpretation: R
- Bioinformatics Workflows: Build and manage bioinformatics pipelines for sequencing data processing, including quality control and analysis using tools like DADA2.
- Statistical Genetics and Genomics: Analyse genetic variations, microbial diversity metrics, and functional gene prediction using specialized statistical methods.
Project start
Fall 2024
Contact Information:
Mentor
sfernan5@nd.edu
Graduate Student
Name of project director or principal investigator
Hope Hollocher
Email address of project director or principal investigator
hholloch@nd.edu
1 sp. | 11 appl.
Hours per week
1 credit / 3-6 hours
Project categories
Biological Sciences